Chicory sesquiterpene lactones as basis for bioinsecticides

General introduction

In integrated crop protection, the choice of approved insecticides is becoming increasingly limited, while sustainable alternatives remain scarce. Natural substances derived from plants are a promising source. The SESQUICHIC research project is investigating the extent to which sesquiterpene lactones (SLs; bitter defense compounds) from the composite family (Asteraceae) can be used. It is known that they correlate demonstrably with pest resistance. In chicory, SL-free mutants appear to be extremely susceptible to thrips, which underlines the importance of SLs. Research is now being conducted to determine which specific SL molecules work, how they work exactly, and which chemical properties are important in this regard. 

Research approach

The biosynthesis of SLs in chicory is being further clarified and the role of individual SLs in resistance is being precisely determined. The team is mapping the potential of these compounds as bioinsecticides. To this end, natural product chemistry, genome editing, multi-omics (integrated analysis of genes, proteins, and metabolites), and standardized bioassays are being combined. The results will provide pre-breeding material for chicory breeding (resistance targets), optimized extraction and production methods, and well-characterized lead molecules for further development.

Relevance/Valorisation

Integrated crop protection needs new approved insecticides. The SESQUICHIC project is expected to deliver well-characterized molecules that could lead to the development of new bioinsecticides. Bioinsecticides contribute to a circular bioeconomy by valorizing SL-rich chicory by-products. Synthetic insecticides that are disappearing from the market are being partially replaced by sustainable, renewable alternatives.

Funding provider(s)
FWO - Fonds Wetenschappelijk Onderzoek