Deposition and depletion of five anticoccidials in eggs

Leen Mortier, Anne-Catherine Huet, Els Daeseleire, Gerard Huyghebaert, Terrence Fodey, Christopher Elliott, Philippe Delahaut, Carlos Van Peteghem

    Research output: Contribution to journalA1: Web of Science-articlepeer-review

    Abstract

    Anticoccidials are compounds that are widely used as feed additives to prevent and treat coccidiosis. They are licensed for use in a prescribed concentration and during a certain time interval for broilers and pullets but not for laying hens. It was shown in the past that carry-over at the feeding mill is found to be the main reason for the presence of residues in eggs. An animal experiment was set up to investigate the effect of carry-over at the feeding mill on the presence of residues of anticoccidials in eggs. For the compounds diclazuril, robenidine, halofuginone and nicarbazin in combination with narasin, two concentration levels were tested: the maximum allowed concentration for broilers (100%) and a concentration corresponding to 5% carry-over during feed preparation. Also dimetridazole was included in the experiment but only at one concentration level. Eggs were sampled during treatment (14 days) and for a period of 30 days after withdrawal of the anticoccidial-containing feed. Residues were determined, and deposition and depletion curves were generated. Analyses were performed by ELISA and LC-MS/MS. For all compounds, substantial residues could be found in the 5% groups, which points out the risk of carry-over at the feeding mill. The distribution of the residues between egg yolk and white was determined by analyzing both fractions.
    Original languageEnglish
    JournalJournal of Agricultural and Food Chemistry
    Volume53
    Issue number18
    Pages (from-to)7142-7149
    Number of pages8
    ISSN0021-8561
    DOIs
    Publication statusPublished - 2005

    Keywords

    • Animal Feed
    • Animals
    • Chickens
    • Coccidiostats
    • Egg White
    • Egg Yolk
    • Eggs
    • Female
    • Kinetics

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