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Abstract
This study addresses the potential association of Escherichia coli O157:H7 genetic clusters with severe clinical manifestations in humans. The genotypes used in this model-based clustering had been delineated on the basis of lineage-specific polymorphism assay, Shiga toxin-encoding bacteriophage insertion site assay, clade typing, tir (A255T) polymorphism, variant analysis of Shiga toxin 2 gene, and antiterminator Q genes. Based on this model, the distribution of genotypes among tested strains suggested the presence of 6 main genetic clusters of E. coli O157:H7 strains. Clusters 1 and 3 were observed to be more frequent among E. coli O157:H7 strains isolated from bloody diarrhea and hemolytic uremic syndrome, respectively. Consequently, our findings supported the growing evidence of the existence of distinct genotypes of E. coli O157:H7 that differ in their virulence levels to human.
Original language | English |
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Journal | Diagnostic microbiology and infectious disease |
Volume | 83 |
Issue number | 2 |
Pages (from-to) | 198-202 |
Number of pages | 5 |
DOIs | |
Publication status | Published - 2015 |
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Dive into the research topics of 'Model-based clustering of Escherichia coli O157:H7 genotypes and their potential association with clinical outcome in human infections'. Together they form a unique fingerprint.Projects
- 1 Finished
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IDESTEC: Intensive identification of human pathogenic shigatoxin producting Escherichia coli (STEC) in Belgium
De Reu, K. (ProjectSupervisor), Heyndrickx, M. (Project Manager) & Verhaegen, B. (Former PhD Student)
1/10/12 → 30/09/14
Project: Research