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Abstract
Veterinary drugs, such as antimicrobial compounds, are widely used in poultry and may lead to the presence of residues in matrices of animal origin, such as muscle and liver tissue. In this study, broilers received an experimental feed containing sulfadiazine or doxycycline at cross-contamination levels of 2.5, 5 and 10% of the therapeutic dose in feed. Breast and thigh muscle and liver samples were collected during treatment and depletion period and analysed via liquid chromatography-tandem mass spectrometry (LC-MS/MS). Concentrations reached a plateau phase 3-5 days after the start of experimental feeding. A rapid depletion of residues was noted after withdrawal of the experimental feed. No significant differences in measured concentrations were observed between the various muscle types. Residue concentrations for some experimental groups; the 10% group of sulfadiazine and the 5 and 10% group of doxycycline, however, exceeded their corresponding maximum residue limits (MRLs).
Original language | English |
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Journal | Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment |
Volume | 29 |
Issue number | 2 |
Pages (from-to) | 180-188 |
Number of pages | 9 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Aging
- Animal Feed
- Animals
- Anti-Bacterial Agents
- Chickens
- Chromatography, Liquid
- Dose-Response Relationship, Drug
- Doxycycline
- Drug Residues
- Food Contamination
- Liver
- Muscle, Skeletal
- Sulfadiazine
- Tandem Mass Spectrometry
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Dive into the research topics of 'Residues of sulfadiazine and doxycycline in broiler liver and muscle tissue due to cross-contamination of feed'. Together they form a unique fingerprint.Projects
- 1 Finished
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RESPOUL: Development of a model for the determination of transfer factors of residues in poultry
Daeseleire, E. (Project Manager), Delezie, E. (Researcher) & Vandenberge, V. (Former Researcher)
1/06/08 → 31/05/12
Project: Research