Residues of sulfadiazine and doxycycline in broiler liver and muscle tissue due to cross-contamination of feed

V Vandenberge, E Delezie, G Huyghebaert, P Delahaut, E Daeseleire, S Croubels

    Research output: Contribution to journalA1: Web of Science-articlepeer-review

    Abstract

    Veterinary drugs, such as antimicrobial compounds, are widely used in poultry and may lead to the presence of residues in matrices of animal origin, such as muscle and liver tissue. In this study, broilers received an experimental feed containing sulfadiazine or doxycycline at cross-contamination levels of 2.5, 5 and 10% of the therapeutic dose in feed. Breast and thigh muscle and liver samples were collected during treatment and depletion period and analysed via liquid chromatography-tandem mass spectrometry (LC-MS/MS). Concentrations reached a plateau phase 3-5 days after the start of experimental feeding. A rapid depletion of residues was noted after withdrawal of the experimental feed. No significant differences in measured concentrations were observed between the various muscle types. Residue concentrations for some experimental groups; the 10% group of sulfadiazine and the 5 and 10% group of doxycycline, however, exceeded their corresponding maximum residue limits (MRLs).
    Original languageEnglish
    JournalFood Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
    Volume29
    Issue number2
    Pages (from-to)180-188
    Number of pages9
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Aging
    • Animal Feed
    • Animals
    • Anti-Bacterial Agents
    • Chickens
    • Chromatography, Liquid
    • Dose-Response Relationship, Drug
    • Doxycycline
    • Drug Residues
    • Food Contamination
    • Liver
    • Muscle, Skeletal
    • Sulfadiazine
    • Tandem Mass Spectrometry

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