Validation of the βeta-s.t.a.r. Combo for fast screening of raw milk on the presence of ß-lactam antibiotics and tetracyclines

Wim Reybroeck; Sigrid Ooghe

Validation of the βeta-s.t.a.r. Combo for fast screening of raw milk on the presence of ß-lactam antibiotics and tetracyclines

Research output: Chapter in Book/Report/Conference proceeding › C1: Articles in proceedings

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Abstract

The 5-minute test ßeta-s.t.a.r. Combo (Neogen Corporation, Lansing, MI) was validated at ILVO-T&V according to Commission Decision 2002/657/EC and the CRL Guidelines for the validation of screening methods by determination of the test specificity, detection capabilities and test robustness.
In the validation study the test showed to be very specific as a real interference was only caused by clavulanic acid at 700 µg/kg and above. The ßeta-s.t.a.r. Combo detects all ß-lactams and tetracyclines with a MRL in milk at their respective MRL except for cefalexin and desfuroylceftiofur.
Positive results for milk with an abnormal composition/quality should be considered with caution since interferences (false positive results) were observed. Retesting of initially positive milk samples could be a recommendation.

Original language	English
Title of host publication	Residues of veterinary drugs in food : Proceedings of the EuroResidue VII Conference, Egmond aan Zee, The Netherlands, 14-16 May 2012
Editors	Robert Schilt
Number of pages	6
Volume	2
Publication date	2012
Pages	557-562
ISBN (Print)	978-94-6173-318-4
Publication status	Published - 2012
Event	EuroResidue VII Conference on Residues of Veterinary Drugs in Food - Egmond aan Zee, Egmond aan Zee, Netherlands Duration: 14-May-2012 → 16-May-2012

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VALIDATIEANTIBIO: Validation of screening tests of antibiotic residues for kit manufacturers
Reybroeck, W., Heyndrickx, M. & Ooghe, S.
1/01/10 → …
Project: Research

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title = "Validation of the βeta-s.t.a.r. Combo for fast screening of raw milk on the presence of {\ss}-lactam antibiotics and tetracyclines",

abstract = "The 5-minute test {\ss}eta-s.t.a.r. Combo (Neogen Corporation, Lansing, MI) was validated at ILVO-T&V according to Commission Decision 2002/657/EC and the CRL Guidelines for the validation of screening methods by determination of the test specificity, detection capabilities and test robustness. In the validation study the test showed to be very specific as a real interference was only caused by clavulanic acid at 700 µg/kg and above. The {\ss}eta-s.t.a.r. Combo detects all {\ss}-lactams and tetracyclines with a MRL in milk at their respective MRL except for cefalexin and desfuroylceftiofur. Positive results for milk with an abnormal composition/quality should be considered with caution since interferences (false positive results) were observed. Retesting of initially positive milk samples could be a recommendation. ",

author = "Wim Reybroeck and Sigrid Ooghe",

year = "2012",

language = "English",

isbn = "978-94-6173-318-4",

volume = "2",

pages = "557--562",

editor = "Schilt, {Robert }",

booktitle = "Residues of veterinary drugs in food",

note = "null ; Conference date: 14-05-2012 Through 16-05-2012",

}

Reybroeck, W & Ooghe, S 2012, Validation of the βeta-s.t.a.r. Combo for fast screening of raw milk on the presence of ß-lactam antibiotics and tetracyclines. in R Schilt (ed.), Residues of veterinary drugs in food: Proceedings of the EuroResidue VII Conference, Egmond aan Zee, The Netherlands, 14-16 May 2012. vol. 2, pp. 557-562, EuroResidue VII Conference on Residues of Veterinary Drugs in Food, Egmond aan Zee, Netherlands, 14/05/12.

Validation of the βeta-s.t.a.r. Combo for fast screening of raw milk on the presence of ß-lactam antibiotics and tetracyclines. / Reybroeck, Wim ; Ooghe, Sigrid.

Residues of veterinary drugs in food: Proceedings of the EuroResidue VII Conference, Egmond aan Zee, The Netherlands, 14-16 May 2012. ed. / Robert Schilt. Vol. 2 2012. p. 557-562.

Research output: Chapter in Book/Report/Conference proceeding › C1: Articles in proceedings

TY - CHAP

T1 - Validation of the βeta-s.t.a.r. Combo for fast screening of raw milk on the presence of ß-lactam antibiotics and tetracyclines

AU - Reybroeck, Wim

AU - Ooghe, Sigrid

PY - 2012

Y1 - 2012

N2 - The 5-minute test ßeta-s.t.a.r. Combo (Neogen Corporation, Lansing, MI) was validated at ILVO-T&V according to Commission Decision 2002/657/EC and the CRL Guidelines for the validation of screening methods by determination of the test specificity, detection capabilities and test robustness. In the validation study the test showed to be very specific as a real interference was only caused by clavulanic acid at 700 µg/kg and above. The ßeta-s.t.a.r. Combo detects all ß-lactams and tetracyclines with a MRL in milk at their respective MRL except for cefalexin and desfuroylceftiofur. Positive results for milk with an abnormal composition/quality should be considered with caution since interferences (false positive results) were observed. Retesting of initially positive milk samples could be a recommendation.

AB - The 5-minute test ßeta-s.t.a.r. Combo (Neogen Corporation, Lansing, MI) was validated at ILVO-T&V according to Commission Decision 2002/657/EC and the CRL Guidelines for the validation of screening methods by determination of the test specificity, detection capabilities and test robustness. In the validation study the test showed to be very specific as a real interference was only caused by clavulanic acid at 700 µg/kg and above. The ßeta-s.t.a.r. Combo detects all ß-lactams and tetracyclines with a MRL in milk at their respective MRL except for cefalexin and desfuroylceftiofur. Positive results for milk with an abnormal composition/quality should be considered with caution since interferences (false positive results) were observed. Retesting of initially positive milk samples could be a recommendation.

M3 - C1: Articles in proceedings

SN - 978-94-6173-318-4

VL - 2

SP - 557

EP - 562

BT - Residues of veterinary drugs in food

A2 - Schilt, Robert

Y2 - 14 May 2012 through 16 May 2012

ER -

Validation of the βeta-s.t.a.r. Combo for fast screening of raw milk on the presence of ß-lactam antibiotics and tetracyclines

Abstract

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VALIDATIEANTIBIO: Validation of screening tests of antibiotic residues for kit manufacturers

Cite this