Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries

Evelien Van Rymenant; Charlotte Grootaert; Katrijn Beerens; Paul W. Needs; Paul A. Kroon; Asimina Kerimi; Gary Williamson; Rocío García-Villalba; Antonio González-Sarrías; Francisco Tomas-Barberan; John Van Camp; Johan Van de Voorde

doi:10.1039/C7FO01273J

Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries

Evelien Van Rymenant, Charlotte Grootaert, Katrijn Beerens, Paul W. Needs, Paul A. Kroon, Asimina Kerimi, Gary Williamson, Rocío García-Villalba, Antonio González-Sarrías, Francisco Tomas-Barberan, John Van Camp, Johan Van de Voorde

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate-not their glucuronidated forms or ferulic acid-caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.

Original language	English
Journal	Food and Function
Volume	8
Issue number	12
Pages (from-to)	4331-4335
Number of pages	5
ISSN	2042-650X
DOIs	https://doi.org/10.1039/C7FO01273J
Publication status	Published - 1-Dec-2017
Externally published	Yes

Keywords

B530-cardiovascular-system
Vasorelaxation
Polyphenol
Polyphenol metabolites
Ex vivo

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10.1039/C7FO01273J

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Van Rymenant, E., Grootaert, C., Beerens, K., Needs, P. W., Kroon, P. A., Kerimi, A., Williamson, G., García-Villalba, R., González-Sarrías, A., Tomas-Barberan, F., Van Camp, J., & Van de Voorde, J. (2017). Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries. Food and Function, 8(12), 4331-4335. https://doi.org/10.1039/C7FO01273J

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title = "Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries",

abstract = "Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate-not their glucuronidated forms or ferulic acid-caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.",

keywords = "B530-cardiovascular-system, Vasorelaxation, Blood pressure, Isometric tension recording, Polyphenols, Metabolites, Bioavailability, Vasorelaxation, Polyphenol, Polyphenol metabolites, Ex vivo",

author = "{Van Rymenant}, Evelien and Charlotte Grootaert and Katrijn Beerens and Needs, {Paul W.} and Kroon, {Paul A.} and Asimina Kerimi and Gary Williamson and Roc{\'i}o Garc{\'i}a-Villalba and Antonio Gonz{\'a}lez-Sarr{\'i}as and Francisco Tomas-Barberan and {Van Camp}, John and {Van de Voorde}, Johan",

year = "2017",

month = dec,

day = "1",

doi = "10.1039/C7FO01273J",

language = "English",

volume = "8",

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journal = "Food and Function",

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Van Rymenant, E, Grootaert, C, Beerens, K, Needs, PW, Kroon, PA, Kerimi, A, Williamson, G, García-Villalba, R, González-Sarrías, A, Tomas-Barberan, F, Van Camp, J & Van de Voorde, J 2017, 'Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries', Food and Function, vol. 8, no. 12, pp. 4331-4335. https://doi.org/10.1039/C7FO01273J

TY - JOUR

T1 - Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries

AU - Van Rymenant, Evelien

AU - Grootaert, Charlotte

AU - Beerens, Katrijn

AU - Needs, Paul W.

AU - Kroon, Paul A.

AU - Kerimi, Asimina

AU - Williamson, Gary

AU - García-Villalba, Rocío

AU - González-Sarrías, Antonio

AU - Tomas-Barberan, Francisco

AU - Van Camp, John

AU - Van de Voorde, Johan

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate-not their glucuronidated forms or ferulic acid-caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.

AB - Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate-not their glucuronidated forms or ferulic acid-caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.

KW - B530-cardiovascular-system

KW - Vasorelaxation

KW - Blood pressure

KW - Isometric tension recording

KW - Polyphenols

KW - Metabolites

KW - Bioavailability

KW - Vasorelaxation

KW - Polyphenol

KW - Polyphenol metabolites

KW - Ex vivo

U2 - 10.1039/C7FO01273J

DO - 10.1039/C7FO01273J

M3 - A1: Web of Science-article

C2 - 29138782

SN - 2042-650X

VL - 8

SP - 4331

EP - 4335

JO - Food and Function

JF - Food and Function

IS - 12

ER -

Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries

Abstract

Keywords

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