Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods

René Feyereisen, Wannes Dermauw, Thomas Van Leeuwen

Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikelpeer review


The recent accumulation of molecular studies on mutations in insects, ticks and mites conferring resistance to insecticides, acaricides and biopesticides is reviewed. Resistance is traditionally classified by physiological and biochemical criteria, such as target-site insensitivity and metabolic resistance. However, mutations are discrete molecular changes that differ in their intrinsic frequency, effects on gene dosage and fitness consequences. These attributes in turn impact the population genetics of resistance and resistance management strategies, thus calling for a molecular genetic classification. Mutations in structural genes remain the most abundantly described, mostly in genes coding for target proteins. These provide the most compelling examples of parallel mutations in response to selection. Mutations causing upregulation and downregulation of genes, both in cis (in the gene itself) and in trans (in regulatory processes) remain difficult to characterize precisely. Gene duplications and gene disruption are increasingly reported. Gene disruption appears prevalent in the case of multiple, hetero-oligomeric or redundant targets.
Oorspronkelijke taalNederlands
TijdschriftPesticide biochemistry and physiology
Pagina's (van-tot)61-77
Aantal pagina’s17
PublicatiestatusGepubliceerd - 1-jun.-2015


  • Gene amplification
  • Gene disruption
  • Gene duplication
  • Point mutation
  • Selection
  • Transposable element

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