In vivo effect of ACE inhibiting in mealworms on ovarian composition and ecdysteroid amounts

Nadia Soltani-Mazouni; D. Bouteldja; Els Lemeire; Guy Smagghe

In vivo effect of ACE inhibiting in mealworms on ovarian composition and ecdysteroid amounts

Nadia Soltani-Mazouni, D. Bouteldja, Els Lemeire, Guy Smagghe

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Captopril is an inhibitor of angiotensin converting enzyme (ACE) used against arterial hypertension in mammals. The aim of this study was to evaluate captopril in the mealworm Tenebio molitor (Coleoptera: Tenebrionidae). The drug was diluted in acetone and administered topically (10μg/3μl) on newly emerged adult females. The biochemical composition (proteins,
lipids, carbohydrates, nucleic acids) and the ecdysteroid amounts of ovaries were determined at day 4 following treatment corresponding to the end of the vitellogenesis process. Biochemical analyses revealed that captopril applied in vivo reduced both total protein, lipid and carbohydrate amounts of ovaries, respectively. In addition, measurement of ecdysteroids by
an enzyme-immunoassay indicated a significant decrease in ovarian ecdysteroid amounts. As a consequence, the reduction of reproductive capacity is possibly related to ecdysteroid production. Further experiments are needed to determine the action mechanism of captopril and the functions of ACE in insects.

Oorspronkelijke taal	Engels
Artikel nummer	18399495
Tijdschrift	Communications in Agricultural and Applied Biological Sciences
Volume	72
Exemplaarnummer	3
Pagina's (van-tot)	623-627
Aantal pagina’s	5
ISSN	1379-1176
Publicatiestatus	Gepubliceerd - 2007
Extern gepubliceerd	Ja

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B410-landbouwhydrologie

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@article{0f579a2080734625942480578cdb495c,

title = "In vivo effect of ACE inhibiting in mealworms on ovarian composition and ecdysteroid amounts",

abstract = "Captopril is an inhibitor of angiotensin converting enzyme (ACE) used against arterial hypertension in mammals. The aim of this study was to evaluate captopril in the mealworm Tenebio molitor (Coleoptera: Tenebrionidae). The drug was diluted in acetone and administered topically (10μg/3μl) on newly emerged adult females. The biochemical composition (proteins,lipids, carbohydrates, nucleic acids) and the ecdysteroid amounts of ovaries were determined at day 4 following treatment corresponding to the end of the vitellogenesis process. Biochemical analyses revealed that captopril applied in vivo reduced both total protein, lipid and carbohydrate amounts of ovaries, respectively. In addition, measurement of ecdysteroids byan enzyme-immunoassay indicated a significant decrease in ovarian ecdysteroid amounts. As a consequence, the reduction of reproductive capacity is possibly related to ecdysteroid production. Further experiments are needed to determine the action mechanism of captopril and the functions of ACE in insects.",

keywords = "B410-agricultural-hydrology, Tenebrio molitor, Reproduction, Captopril, Ecdysteroids, Ovaries, Lipids, Proteins, Carbohydrates, Nucleic acids",

author = "Nadia Soltani-Mazouni and D. Bouteldja and Els Lemeire and Guy Smagghe",

year = "2007",

language = "English",

volume = "72",

pages = "623--627",

journal = "Communications in Agricultural and Applied Biological Sciences",

issn = "1379-1176",

publisher = "UGent",

number = "3",

}

TY - JOUR

T1 - In vivo effect of ACE inhibiting in mealworms on ovarian composition and ecdysteroid amounts

AU - Soltani-Mazouni, Nadia

AU - Bouteldja, D.

AU - Lemeire, Els

AU - Smagghe, Guy

PY - 2007

Y1 - 2007

N2 - Captopril is an inhibitor of angiotensin converting enzyme (ACE) used against arterial hypertension in mammals. The aim of this study was to evaluate captopril in the mealworm Tenebio molitor (Coleoptera: Tenebrionidae). The drug was diluted in acetone and administered topically (10μg/3μl) on newly emerged adult females. The biochemical composition (proteins,lipids, carbohydrates, nucleic acids) and the ecdysteroid amounts of ovaries were determined at day 4 following treatment corresponding to the end of the vitellogenesis process. Biochemical analyses revealed that captopril applied in vivo reduced both total protein, lipid and carbohydrate amounts of ovaries, respectively. In addition, measurement of ecdysteroids byan enzyme-immunoassay indicated a significant decrease in ovarian ecdysteroid amounts. As a consequence, the reduction of reproductive capacity is possibly related to ecdysteroid production. Further experiments are needed to determine the action mechanism of captopril and the functions of ACE in insects.

AB - Captopril is an inhibitor of angiotensin converting enzyme (ACE) used against arterial hypertension in mammals. The aim of this study was to evaluate captopril in the mealworm Tenebio molitor (Coleoptera: Tenebrionidae). The drug was diluted in acetone and administered topically (10μg/3μl) on newly emerged adult females. The biochemical composition (proteins,lipids, carbohydrates, nucleic acids) and the ecdysteroid amounts of ovaries were determined at day 4 following treatment corresponding to the end of the vitellogenesis process. Biochemical analyses revealed that captopril applied in vivo reduced both total protein, lipid and carbohydrate amounts of ovaries, respectively. In addition, measurement of ecdysteroids byan enzyme-immunoassay indicated a significant decrease in ovarian ecdysteroid amounts. As a consequence, the reduction of reproductive capacity is possibly related to ecdysteroid production. Further experiments are needed to determine the action mechanism of captopril and the functions of ACE in insects.

KW - B410-agricultural-hydrology

KW - Tenebrio molitor

KW - Reproduction

KW - Captopril

KW - Ecdysteroids

KW - Ovaries

KW - Lipids

KW - Proteins

KW - Carbohydrates

KW - Nucleic acids

M3 - A1: Web of Science-article

SN - 1379-1176

VL - 72

SP - 623

EP - 627

JO - Communications in Agricultural and Applied Biological Sciences

JF - Communications in Agricultural and Applied Biological Sciences

IS - 3

M1 - 18399495

ER -

In vivo effect of ACE inhibiting in mealworms on ovarian composition and ecdysteroid amounts

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