Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 13: Diaminopyrimidines: trimethoprim


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The specific concentrations of trimethoprim in non-target feed for food-producing animals below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for trimethoprim was estimated. Uncertainties and data gaps associated to the levels reported were addressed. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. No suitable data for the assessment were available. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for trimethoprim.
Oorspronkelijke taalEngels
TijdschriftEFSA Journal
Pagina's (van-tot)e06865
Aantal pagina’s21
PublicatiestatusGepubliceerd - 1-okt-2021


  • Feed Antimicrobial Resistance Selection Concentration (FARSC)
  • Trimethoprim
  • antimicrobial resistance
  • food-producing animals
  • growth promotion
  • sub-inhibitory concentration
  • yield increase

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