Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients

J L Willems, J P Langenberg, A G Verstraete, M De Loose, B Vanhaesebroeck, G Goethals, F M Belpaire, W A Buylaert, D Vogelaers, F Colardyn

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    Uittreksel

    Using pharmacokinetic data from healthy human volunteers in a bicompartmental pharmacokinetic model, a repeated dose scheme for pralidoxime methylsulphate (Contrathion) was developed producing plasma levels remaining above the assumed "therapeutic concentration" of 4 mg.l-1. Using the same data, it was found that a concentration of 4 mg.l-1 could also be obtained by a loading dose of 4.42 mg.kg-1 followed by a maintenance dose of 2.14 mg.kg-1.h-1. In order to study the pharmacokinetic behaviour of pralidoxime in poisoned patients, this continuous infusion scheme was then applied in nine cases of organophosphorus poisoning (agents: ethyl parathion, ethyl and methyl parathion, dimethoate and bromophos), and the pralidoxime plasma levels were determined. The mean plasma levels obtained in the various patients varied between 2.12 and 9 mg.l-1. Pharmacokinetic data were calculated, giving a total body clearance of 0.57 +/- 0.27 l.kg-1.h-1 (mean +/- SD), an elimination half-life of 3.44 +/- 0.90 h, and a volume of distribution of 2.77 +/- 1.45 l.kg-1.
    TaalEngels
    TijdschriftArchives of Toxicology
    Volume66
    Exemplaarnummer4
    Pagina's (van-tot)260-6
    Aantal pagina's7
    ISSN0340-5761
    StatusGepubliceerd - 1992

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