Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species

EFSA FEEDAP Panel, Lieve Herman

Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikelpeer review

Uittreksel

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of concentrated liquid l-lysine (base, minimum 50%) and l-lysine monohydrochloride (HCl, minimum 99%) produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCCM 80216) as nutritional additives for all animal species. Neither the production strain nor its recombinant DNA was detected in the final products. The additives do not pose any safety concern associated with the genetic modification of the production strain. Concentrated liquid l-lysine (base) and l-lysine HCl produced by C. glutamicumKCCM 80216 do not represent a risk for the target species, the consumer and the environment. From the results of studies on the safety for the user of concentrated liquid l-lysine (base) and l-lysine HCl produced by a different production strain, it was possible to conclude on the safety for the user of the products under assessment. The concentrated liquid l-lysine (base) and the l-lysine HCl are not irritant to skin or eyes or skin sensitiser. l-lysine HCl is not hazardous by inhalation. l-lysine HCl and concentrated liquid l-lysine (base) are considered as efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
Oorspronkelijke taalEngels
TijdschriftEFSA Journal
Volume18
Exemplaarnummer12
Pagina's (van-tot)e06334
Aantal pagina’s16
ISSN1831-4732
DOI's
PublicatiestatusGepubliceerd - dec.-2020

Trefwoorden

  • Corynebacterium glutamicum
  • concentrated liquid l-lysine (base)
  • efficacy
  • lysine monohydrochloride
  • nutritional additive
  • safety
  • their salts and analogues’
  • ‘amino acids

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