Safety and efficacy of l-valine produced by fermentation using Corynebacterium glutamicumCGMCC 7.358 as a feed additive for all animal species


Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikelpeer review


Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-valine produced by fermentation using a non-genetically modified strain of Corynebacterium glutamicum (CGMCC 7.358). The additive is intended to be used in feed and water for drinking for all animal species and categories. The production strain meets the qualifications for the qualified presumption of safety (QPS) approach to safety assessment and is considered safe. l-Valine produced using C. glutamicumCGMCC 7.358 is safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species, for the consumer and for the environment. No conclusion could be drawn on the potential of l-valine produced using C. glutamicumCGMCC 7.358 to be toxic by inhalation, irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The product l-valine produced by fermentation using C. glutamicumCGMCC 7.358 is regarded as an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. For the supplemental l-valine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.
Oorspronkelijke taalEngels
TijdschriftEFSA Journal
Pagina's (van-tot)e06286
Aantal pagina’s12
PublicatiestatusGepubliceerd - nov-2020


  • C. glutamicumCGMCC 7.358
  • amino acids
  • efficacy
  • l-valine
  • nutritional additive
  • safety

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