Short communication: Pasteurization of Milk Abolisches Bovine Herpesvirus 4 infectivity

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    Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus
    highly prevalent in the cattle population that has
    been isolated from the milk and the serum of healthy
    infected cows. Several studies reported the sensitivity
    and the permissiveness of some human cells to BoHV-4
    infection. Moreover, our recent study demonstrated
    that some human cells sensitive but not permissive to
    BoHV-4 support a persistent infection protecting them
    from tumor necrosis factor-α–induced apoptosis. Together,
    these observations suggested that BoHV-4
    could represent a danger for public health. To evaluate
    the risk of human infection by BoHV-4 through milk
    or serum derivatives, we investigated the resistance
    of BoHV-4 to the mildest thermal treatments usually
    applied to these products. The results demonstrated
    that milk pasteurization and thermal decomplementation
    of serum abolish BoHV-4 infectivity by inactivation
    of its property to enter permissive cells. Consequently,
    our results demonstrate that these treatments
    drastically reduce the risk of human infection
    by BoHV-4 through treated milk or serum derivatives.
    (Key words: bovine herpesvirus 4, milk, serum, pasteurization)
    Oorspronkelijke taalEngels
    TijdschriftJournal of Dairy Science
    Pagina's (van-tot)3079-3083
    PublicatiestatusGepubliceerd - 24-mei-2005

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